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Lidocaine Powder Pharmaceutical Intermediate CAS 137-58-6

Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).
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  • 137-58-6
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Density 1.0±0.1 g/cm3
Boiling Point 372.7±52.0 °C at 760 mmHg
Melting Point 66-69°C
Molecular Formula C14H22N2O
Molecular Weight 234.337
Flash Point 179.2±30.7 °C
Exact Mass 234.173218
PSA 32.34000
LogP 3.63
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.512
Storage condition Store at RT
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility practically insoluble



137-58-6 lidocaine


137-58-6 lidocaine


1ae77ee7ea598a86c01ed55764238e61_MKE



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