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Topical Anesthetic Pramoxine Hydrochloride/Pramoxine HCl CAS 637-58-1 Used As An Antipruritic

  Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.
  
The popular itch creams Gold Bond and some forms of Calamine Lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble.
 
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  • 637-58-1
  • Moker




 Physical and chemical properties of pramoxine hydrochloride

Boiling point 427ºC at 760 mmHg
Melting point 181-183ºC
Molecular formula 17 H 28 ClNO 3
Molecular weight 329.862
Flash point 123.5ºC
Precise quality 329.175781
PSA 30.93000
LogP 3.70650
Appearance traits White or off-white crystalline powder

637-58-1 (5)

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Density 1.28g/cm3
Boiling Point 334.3ºC at 760 mmHg
Molecular Formula C10H10NaO3+
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