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Pharmaceutical Intermediate Powder
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Corey lactone 4-phenylbenzoate is a synthetic intermediate used in the manufacture of some prostaglandin derivatives. It has been used as a false name by some designer drug manufacturers as a label to sell substituted cathinone derivatives after the banning of mephedrone and related drugs in some jurisdictions , but there is no evidence to suggest that Corey lactone 4-phenylbenzoate has any stimulant effects in its own right.
(-)-Corey Lactone Benzoate is a corey lactone derivative used in the preparation prostaglandin analogues for use as vasolidator as well as EP4 receptor agonists.
(-)-Corey Lactone Diol is an intermediate of Iloprost and shows inhibitory activity towards β-lactamase. Iloprost is a synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. Contact me: Whatsapp/Telegram: +86 17755167119 Wickr Me:milazhang Wechat: +86 17755167119 Email:mila@moker-china.com Gmail: milazhang1221@gmail.com
4-Chloro-1-methylpiperidine is a reactant in the synthesis of indole and benzimidazole piperazines as histamine H4 receptor antagonist. Contact me: Whatsapp/Telegram: +86 17755167119 Wickr Me:milazhang Wechat: +86 17755167119 Email:mila@moker-china.com Gmail: milazhang1221@gmail.com
Carnosine (English: carnosine), the scientific name β-alanyl-L-histidine (β-alanyl-L-histidine), is a kind of two amino acids composed of β-alanine and L-histidine. Peptide. The tissues of muscles and brain contain very high concentrations of carnosine. Carnosine was discovered by the Russian chemist Gulevich along with carnitine. Studies in the United Kingdom, South Korea, Russia and other countries have shown that carnosine has a strong antioxidant capacity and is beneficial to the human body. Carnosine has been proven to scavenge reactive oxygen radicals (ROS) and α-β unsaturated aldehydes formed by excessive oxidation of fatty acids in cell membranes during oxidative stress. Many studies have found that N-acetylcarnosine has a good effect in the prevention and treatment of cataracts. One of the studies has shown that carnosine can improve cataracts caused by turbidity of the rat's lens caused by exposure to guanidine. Although these claims support the function of carnosine. Treatment of cataracts and other hypothetical benefits to the eye, but so far, it has not received sufficient support from the mainstream medical community. For example, the Royal Ophthalmology Department of the United Kingdom once claimed that carnosine is neither safe nor effective in the local treatment of cataracts. In a 2002 research report, it was pointed out that carnosine can improve the relationship between children with autism and society and increase the vocabulary used by children with autism. However, the improvement claimed in the research may also come from maturity. , Placebo effect, or other factors not included in this research report. In animal experiments, carnosine supplementation can increase the content of cortisol, which may explain the hyperkinetic symptoms sometimes caused by high-dose carnosine. However, the above study was to inject carnosine into the cerebral ventricle of chickens and cortisol The phenomenon of rising content has not yet appeared in human experiments. In animal experiments, carnosine has been found to delay the growth of cancer cells and prevent oxidative stress caused by alcohol and chronic liver damage caused by alcohol. In mouse experiments, the neuroprotective mechanism of carnosine can prevent permanent brain ischemia. Carnosine can enhance the Hayflick limit of human fibroblasts and the rate of telomere shortening. The maintenance of telomeres may be beneficial to the growth of certain potential cancers, so carnosine is also regarded as a protective agent. It is generally believed that typical vegetarians lack carnosine intake, but it is still unknown whether this will cause adverse effects.
N-Methylformamide (NMF) is a colorless, nearly odorless, organic compound with molecular formula CH3NHCHO, which is a liquid at room temperature. It is infinitely soluble in water. NMF is mainly used as a reagent in various organic syntheses with limited applications as a highly polar solvent. NMF is closely related to other formamides, notably formamide and dimethylformamide (DMF). However, industrial use and production of NMF are far less than for either of these other formamides. DMF is favored over NMF as a solvent due to its greater stability. Annual production of NMF can be assumed to be significantly less than the production of either formamide (100,000 tons) or DMF (500,000 tons).
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